We decipher genetic circuits pivotal in determining viral fates. Our mission not only pivots on understanding the architecture of the fate-dictating genetic circuits, but leverages these design principles to engineer indomitable therapies — therapies envisioned to outsmart viral evolution with a towering genetic barrier. With a particular intrigue in the shadowy realm of latency, oncogenesis, developmental disorders associated with DNA viruses, the transmission mechanics of pandemic potential RNA viruses, we dive deep, exploring, understanding, and innovating to make the next-generation medicine and help human health.